Radonc/BME Medical Image and
Computational Analysis Laboratory
Shruti Siva Kumar
MS, Biomedical Engineering from UF, 2016
PhD, Biomedical Engineering, Aug. 2020


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  1. Honors and Awards
    -- Recipient of 2019 Radiation Research Society Student Training Award
    -- Recipient of 2019 Biomedical Engineering Society Travel Award
    -- Recipient of 2018 Anita B.org Grace Hopper Fellowship Award
    -- Oct. 2017, National BMES Career Development Award ( link).
    -- Nov. 2016, UF College of Engineering Outstanding International Student award ( link).
    -- Dec. 2015, GE Industrial Remix Challenge award winner ( link).

  2. Research Overview

    1. MS Thesis: characterizing patterns of myocardial mechanical disfunction in women treated with radiation to the chest wall for breast cancer.

    Background and Significance
    Radiotherapy (RT) is a critical component of breast cancer management, yielding a substantial survival benefit. However, even with advanced technology for treating the tumor effectively, organs that are in close proximity to the breast, such as the heart, are highly prone to radiation exposure. Each 1 Gy heart dose increases risk of heart events by 7%. Compared with conventional photon (X-ray) therapy, proton therapy (PT) has shown improved target coverage and reduction of exposure of doses to organs at risk. By minimizing the radiation exposure to the heart PT is hypothesized to reduce cardiac toxicity but this effect has not been quantified in human subjects.

    Hypothesis
    Because cardiac injury is a late effect of radiation, early markers could be used to identify new techniques that would improve the therapeutic ratio of treatment within years rather than decades.


    Methods
    We are acquiring cardiac magnetic resonance (CMR) images in 12 patients with left-sided breast cancer undergoing breast or chest-wall photon or proton therapy. Our specific aims are to:
        i. Measure circumferential mechanical strain (percent muscle shortening) in myocardial sub-regions throughout the heart using MR cardiac tagging.
        ii. Measure left ventricle volume, ejection fraction, and perfusion using late gadolinium enhancement

    Results
        i. We have employed Myocardial Tagging technique to track the motion of LV heart wall.
        ii. We have segmented the LV of the heart from the above images using Active Contouring technique.
        iii. We have computed surface meshes and extracted those from the segmented images using mathematical transformations.
        iv. We have also computed strain maps to investigate the wall thickening between Pre-Radiation and Post- Radiation images. This has been done successfully for 2 patients each with an 8 month follow up scan.

    Future work
        i. We will be validating our results for strain computations using phantom heart with known tags and fitting parameters.
        ii. The 6 month datasets will be registered to the CT dataset used for treatment planning to facilitate pixel-wise assessment of dose versus strain and other cardiac parameters.
        iii. We will compare differences in CMR parameters from the 6 month time point to baseline data via a paired t-test.

    2. PhD Thesis: Modeling radiobiological correlations with lung radiation toxicity in breast cancer patients treated with either conventional X-ray versus proton radiation therapy.



  3. National Presentations
    Bradley J, Siva Kumar S, Liang X, Lockney N, Mailhot Vega R, Mendenhall N, Pembroke M, Okunieff P, O’Dell W
          Evaluation of radiographic pulmonary changes and cytokine expressions on a prospective longitudinal clinical trial after radiation therapy for breast cancer: a comparison of proton vs. photon therapy
          Virtual poster to American Society for Radiation Oncology (ASTRO) national conference. #3308, Oct 25. 2020

    Siva Kumar S, Bradley J, Terracino B, Waler A, Zeng E, Klassen C, Rutenberg M, Mendenhall N, Mailhot R, O’Dell W.
          Proton therapy preserves acute left ventricular ejection fraction relative to conventional X-ray therapy in breast cancer.
          American Heart Association Annual Conference. Philadelphia PA:
          Nov. 16, 2019.

    Siva Kumar S, Bradley J, Liang X, Lockney N, Mailhot R, Mendenhall NP, Pembroke M, Okunieff P, O’Dell W.
          Evaluation of radiographic pulmonary changes on serial chest CTs after radiation therapy for breast cancer: a comparison of proton vs. photon therapy.
          65th Annual Meeting of the Radiation Research Society. San Diego, CA:
          Nov. 2, 2019.

    Abraham S, Siva Kumar S, O' Dell W.
          Evaluating Variability in the Measurement of Global Longitudinal Strain with Slice Orientation.
          Biomedical Engineering Society Annual Meeting. Philadelphia, PA:
          Oct. 16, 2019.

    Ravuri S, Siva Kumar S, White RJ, Haight D, O’Dell WG.
          Modeling and quantifying vascular structures in experimental rat lungs.
          Biomedical Engineering Society Annual Meeting. Philadelphia, PA:
          Oct. 16, 2019.

    O’Dell W, Siva Kumar S, Terracino B, Bradley J.
          Proton therapy preserves acute left ventricular ejection fraction relative to conventional X-ray therapy in breast cancer.
          Florida Chapter of the American Association of Physicists in Medicine (FL-AAPM), Fall 2019 meeting. St. Petersburg, FL:
          Sept. 27, 2019.

    Siva Kumar S, Bradley J, Terracino B, Waler A, Zeng E, Klassen C, Rutenberg M, Mendenhall N, Mailhot R, O’Dell W.
          Proton therapy preserves acute left ventricular ejection fraction relative to conventional X-ray therapy in breast cancer.
          Global Cardio-Oncology Summit/Canadian Cardiac Oncology Network Conference. Montreal, CA:
          April 26, 2019.

    Saini A, Siva Kumar S, O’Dell W.
          Measuring lung vessel tree growth during development in pediatric patients.
          Biomedical Engineering Society Annual Meeting. Atlanta GA:
          Oct. 18, 2018.

    Siva Kumar S, Waler A, Bradley J, Klassen C, O’Dell W.
          Computing regional myocardial radiation-dose response in left sided breast cancer patients.
          Anita B.org/Grace Hopper Celebration. Houston, TX: Sept.
          27, 2018.

    Siva Kumar S, Klassen C, Bradley J.
          Quantifying sub-clinical cardiac radiation toxicity in breast cancer patients
          63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico,
          October 15-18, 2017

    O’Dell W, Siva Kumar S, Klassen C, Bradley J.
          Quantifying sub-clinical cardiac radiation toxicity in breast cancer patients
          63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico,
          October 15-18, 2017

    Siva Kumar S, Waler A, Bradley J, Klassen C, O’Dell W.
          Determining Radiation-Induced Subclinical Cardiac Toxicity in Left Sided Breast Cancer Patients using Magnetic Resonance Imaging with Tagging
          BMES Annual Meeting,
          October 11-14, 2017 in Phoenix, AZ

    O’Dell W, Siva Kumar S.
          Determining prolate spheroidal modes of cardiac deformation directly from tagged heart images
          ISMRM 25th Annual Meeting & Exhibition, Hawaii,
          April 22-27, 2017

  4. Related MIACALab projects
    1. Myocardial MRI tagging
    2. Lung radiation dose response

  5. Close Research Collaborators
    1. W. O'Dell (Radiation Oncology Research)
    2. Dr. Julie Bradley
    3. Dr. Paul Okunieff