Dr. O'Dell's PhD and post-doc efforts were in the area of cardiac MR tagging and finite element modeling of myocardial function. He has developed software for computer-assisted contouring of the heart, 3D heart surface modeling, and recently inveted a new approach for tag-based motion reconstruction using a deformable image registration approach and virtual tagged images. We using these tools to quantify =acute and chronic changes in myocardial function in breast cancer patients who receive RT to the chest wall, funded through a pilot grant from the Ocala Royal Dames for Cancer Research.
In out initial data analysis, we are able to measure a decrease in left ventricular ejection fraction in patients receiving conventional X-ray-based therapy, but a stabilization and recovery in LVEF in patients receiving proton therapy.
Figure 1 [A] Dr. O'Dell's beating heart with tags.
[B] 3D plot of circumferential strain in a patient with an infarct secondary to occlussion of the LAD.
[C] FEM mesh depiction of the left ventricle going from a reference to a deformed state.
Blackband, S., Chatham, J., O'Dell, W. and Day, S.
Echo Planar Imaging of Isolated Perfused Rat Hearts at 4.7 T:
A Comparison of Langendorff and Working Heart Preparations
Magnetic Resonance in Medicine 15:240-245, 1990