Radonc/BME Medical Image and
Computational Analysis Laboratory
Carlos Lezcano III
BME, pre-med
2019 UF Research Training Opportunities for Outstanding Leaders program, summer 2019
expected graduation: Spring 2020


email link
  1. Resume (pdf)
  2. Research Overview

    Investigating racial differences in metstatstic breast cancer outcomes


    Background and Significance
    In 2019, over 250,000 women in the United States will be diagnosed with invasive breast cancer. Approximately 11% (26,000) of these women will develop distant metastatic breast cancer (MBC) after an initial diagnosis2 and will account for nearly 2/3 of the 40,610 breast cancer deaths that occur annually. The lungs are the most frequent site for primary cancer and the second most common site for metastases. Among women who die of breast cancer, 55-77% have metastases to the lungs. African American women are 42% more likely to die from breast cancer than their White counterparts even after unequal access to care is accounted for. Late-onset metastatic tumors are theorized to be derived from early-onset lesions. Therefore, eliminating the first stage of metastatic disease could reduce the development of secondary metastatic tumors. Nodules that do not grow measurably in a 6 month frame carry a malignancy risk of less than 10%.

    Hypothesis
    The discrepancy in African American survival rate may result from a higher growth rate of metastatic breast cancer when compared to their White and Hispanic counterparts.

    Methods
    Quantify detected nodule volume and growth across a patient’s treatment period to differentiate active tumors from benign nodules and document for the first time the growth rate of breast cancer metastases versus race.
    The poster below shows my recent findings.

  3. Presentations
    Carlos Lezcano and Walter O'Dell
          Retrospective Analysis of growth Rates of Metastatic cancer in the lung
          Florida Chapter of the American Association of Physicists in Medicine, Tampa FL, Sept. 26, 2019
          Rand the eTOOL Summer Showcase, August 2, 2019

    Related MIACALab projects
    1. Vessel Segmentation

    Close Research Collaborators
    1. W. O'Dell, PhD (Radiation Oncology Research)