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Radonc/BME     Medical Image and
Computational Analysis Laboratory
MR Cardiac Tagging for quantitative assessment of heart function
Investigators: W. O'Dell, Julie Bradley, Christopher Klassen, Shruti Siva Kumar, Pooja Thakare, Vishwas Jindal

Former students: Alexandria Waler, Eric Zeng


Aims
Dr. O'Dell's PhD and post-doc efforts were in the area of cardiac MR tagging and finite element modeling of myocardial function. He has developed software for computer-assisted contouring of the heart, 3D heart surface modeling, and recently inveted a new approach for tag-based motion reconstruction using a deformable image registration approach and virtual tagged images. We using these tools to quantify =acute and chronic changes in myocardial function in breast cancer patients who receive RT to the chest wall, funded through a pilot grant from the Ocala Royal Dames for Cancer Research.

      In out initial data analysis, we are able to measure a decrease in left ventricular ejection fraction in patients receiving conventional X-ray-based therapy, but a stabilization and recovere in LVEF in patients receiving proton therapy.

      In the future we may investigate heart right ventricular function and pulmonary vascular response in children and adults with chronic pulmonary hypertension. Here our ability to segment, label and characterize vascualr structural abnormalities (see that project page here) may prove useful for assessing disease progression, treatment response, and for babies born very prematurely whether their lung vasculature is sufficiently developed to safely remove them from mechanical ventilators.

Figure 1
[A] Dr. O'Dell's beating heart with tags.
[B] 3D plot of circumferential strain in a patient with an infarct secondary to occlussion of the LAD. [C] FEM mesh depiction of the left ventricle going from a reference to a deformed state.



Related National Presentions
  1. O’Dell W, Siva Kumar S, Klassen C, Bradley J.
          Quantifying sub-clinical cardiac radiation toxicity in breast cancer patients
          63rd Annual Meeting of the Radiation Research Society, Cancun, Mexico,
          October 15-18, 2017
  2. Siva Kumar S, Waler A, Bradley J, Klassen C, O’Dell W.
          Determining Radiation-Induced Subclinical Cardiac Toxicity in Left Sided Breast Cancer Patients using Magnetic Resonance Imaging with Tagging
          BMES Annual Meeting,
          October 11-14, 2017 in Phoenix, AZ
  3. O’Dell W, Siva Kumar S.
          Determining prolate spheroidal modes of cardiac deformation directly from tagged heart images
          ISMRM 25th Annual Meeting & Exhibition, Hawaii,
          April 22-27, 2017
Related Publications
  1. O'Dell W.G. and McCulloch, A.D.
          Imaging Three-Dimensional Cardiac Function (1.2M pdf)
          Annual Reviews in Biomedical Engineering, (Nov)2:431-456, 2000
  2. Declerck J., Denney T.S., Ozturk C., O'Dell W. and McVeigh E.R.
          Left ventricular motion reconstruction from planar tagged MR images: a comparison (987k pdf)
          Physics in Medicine & Biology. (June) 45(6):1611-32, 2000
  3. Costa K., May-Newman K., Farr D., O'Dell W., McCulloch A. and Omens J.
          Three-dimensional residual strain in midanterior canine left ventricle (258k pdf)
          American Journal of Physiology, 273:H1968--76, 1997
  4. Guccione, J., O'Dell, W., McCulloch, A. and Hunter, W.
          Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection (2.1M pdf)
          American Journal of Physiology, (Jan)272(1 Pt 2):H469-77, 1997
  5. O'Dell, W., Moore, C., Hunter, W., Zerhouni, E. and McVeigh, E.
          Three-dimensional myocardial deformations: calculation with displacement field fitting to tagged MR images (1.2M pdf)
          Radiology, (June)195:829--835, 1995
  6. Constantinides, C., Westgate, C., O'Dell, W., Zerhouni, E. and McVeigh E.
          A Phased Array Coil for Human Cardiac Imaging (825k pdf)
          Magnetic Resonance in Medicine, (July)34(1):92-98, 1995
  7. O'Dell, W.
          Myocardial Deformation Analysis in the Passive Dog Heart Using High Resolution MRI Tagging (3.9M pdf)
          PhD Thesis, Dept. Biomedical Engineering, Johns Hopkins Univ., 1995
  8. O'Dell, W., Schoeniger, J., Blackband, S. and McVeigh, E.
          A Modified Quadrapole Gradient Set for use in High Resolution MRI Tagging (804k pdf)
          Magnetic Resonance in Medicine, 32:246--250, 1994
  9. Moore, C., O'Dell, W., McVeigh, E. and Zerhouni, E.
          Calculation of Three-Dimensional Left Ventricular Strains from Bi-planar Tagged MR Images (547k pdf)
          The Journal of Magnetic Resonance Imaging, 2:165--175, 1992
  10. Douglas, A., Rodriguez, E., O'Dell, W. and Hunter, W.
          Unique Ventricular Strains During Ejection (3.9M pdf)
          American Journal of Physiology, 260:H1596--H1611, 1991
  11. Blackband, S., Chatham, J., O'Dell, W. and Day, S.
          Echo Planar Imaging of Isolated Perfused Rat Hearts at 4.7 T: A Comparison of Langendorff and Working Heart Preparations
          Magnetic Resonance in Medicine 15:240-245, 1990