-- Selected for the 2018 Biomedical Engineering Summer Internship Program (BESIP) at the NIH
-- Awarded UF BME Society Traval grant to present at the national BMES conference, 2017
-- Awarded most outstanding undergraduate poster at the UF BME Research day 2016
Validating lung vessel sizing
Background and Significance
Changes in vessel number and size are apparent in patients receiving radiation to the lungs, and in the still developing lung of prematuraly born infants.
Our lab has developed software tools to measure the number of and precisely determine the size of blood vessels from 3D CT or MRI scans. Validating that the vessel size estimates are correct is a challenging task that has heretofore not been adequately addressed.
The purpose of the first phase of the research project I will be working on is to validate the vessel sizing algorithm and software package. The second phase is to apply this technology to measure the growht in vessel number and size in extreme-pregerm gestation pediatric patients to quantify the changes in the lungs vasculature with age.
Our approach was to use a semi-realistic 3D reconstruction of the lung vascular anatomy from a healthy volunteer's high-resolution CT data set. From this software model Dr. O'Dell generated a physical 3D phantom using 3D printing technology. We then scanned the physical model on a clinical CT scanner in the UF Health Cancer Center, Department of Radiation Oncology. For ground truth, a digital caliper was used to measure each branch in the model. Each of 64 branches in the physical model was individually labeled for correlation with the software results on the CT scan. Each branch was measured 3 times by Anne Gormaley and David Prida.